Number of COVID-19 cases required in a population to detect SARS-CoV-2 RNA in wastewater in the province of Alberta, Canada: Sensitivity assessmentResearch article Published on 2023-03-012022-10-05 Journal: Journal of environmental sciences (China) [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] analysis Analysis collected Community COVID-19 COVID-19 case COVID-19 cases Critical dataset defined detect detection rate Detection sensitivity Epidemiology Estimated IMPROVE input median negative test number plant positive prevalence of COVID-19 Probability Probit analysis provided required RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity study period Support Surveillance threshold Treatment unique wastewater [DOI] 10.1016/j.jes.2022.04.047 [Article Type] Research article
Getting through a COVID-19 winter: Physical coldness increases the perceived risk of coronavirus diseaseResearch article Published on 2023-01-012022-10-05 Journal: Personality and Individual Differences [Category] 진단, [키워드] Affect assigned Attribute substitution model Chinese conditions Contagion control condition coronavirus coronavirus disease Coverage COVID-19 diagnostic disease Disease risk perception disease transmission Embodiment environmental factor evaluate Evidence Factor feature genetic susceptibility Health increase information less likelihood Local media New coronavirus participant Perceived risk Physical coldness Probability Randomly recruit reported Research risk temperature visceral [DOI] 10.1016/j.paid.2022.111799 [Article Type] Research article
Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levelsArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2-RBD acute respiratory syndrome addition adhere binding complex coronavirus Delta delta variant destabilized effective force spectroscopy highest host cell human ACE2 human Angiotensin-converting enzyme immunization Infection inhibit Interaction investigated molecular dynamics molecular mechanism monoclonal antibody Mutation mutations N501Y Neutralizing neutralizing antibody omicron pathogen-host adhesion. Probability produced RBD Receptor binding domain S477N SARS-CoV-2 SARS-CoV-2 spike protein single-cell single-cell level Spike protein tested the spike protein variant variants virus wild type [DOI] 10.1080/22221751.2022.2128887 PMC 바로가기
Clinical course of patients with chronic limb-threatening ischemia developing COVID-19Article Published on 2022-12-012022-11-16 Journal: Journal of cardiology [Category] 변종, [키워드] 30-Day mortality 95 % CI acute respiratory syndrome added Analysis association calculated Cardiovascular events caused chronic Chronic limb-threatening ischemia claudication clinical Clinical course confidence interval control group coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patient Cox regression analysis demonstrated diagnosis of COVID-19 disease evaluate the effect hazard ratio Healthcare systems high risk increased risk initial IPW Ischemia Japan Mortality mortality risk omicron omicron variant. pandemic Patient patients patients with COVID-19 primary outcome measure Probability proportion reached Regression model reported significantly higher treated Treatment variant was used Weighting [DOI] 10.1016/j.jjcc.2022.07.010 PMC 바로가기
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomesArticle Published on 2022-11-122022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Adaptability Antiviral approved circulating coronavirus correlation COVID-19 cases COVID-19 pandemic develop drug resistance FDA highest hotspot intracellular protein Like M pro main protease Mild-to-moderate mutant Mutation mutations Nirmatrelvir offer omicron predicted Probability protease Protein design reported residue residues resistance resistance mutations robust SARS-CoV-2 SARS-CoV-2 lineage signature Signatures of adaptation. Surveillance unique variant Variation variations viral adaptation viral genome viruses [DOI] 10.1016/j.bbrc.2022.09.010 PMC 바로가기
Characteristics and treatment of hospitalized pregnant women with Coronavirus Disease 2019, COVID-19Research article Published on 2022-11-012022-10-05 Journal: American journal of obstetrics & gynecology MFM [Category] 임상, 치료법, [키워드] 95% confidence interval Admission age black calculated Clinical characteristics clinical trials Cohort COVID-19 COVID-19 vaccination discharge estimate Hispanic Hospitalized identify implementation Inclusion increased risk laboratory-confirmed SARS-CoV-2 infection Latino less MOST network nonpregnant outcome Patient Pregnancy pregnant pregnant patient pregnant women Prevalence prevalence ratio Probability propensity score matching receive Remdesivir reproductive requiring supplemental oxygen SARS-CoV-2 steroids spontaneous abortion Stillbirth Surveillance symptomatic symptoms of COVID-19 Systemic steroid Treatment vaccination with COVID-19 women [DOI] 10.1016/j.ajogmf.2022.100715 [Article Type] Research article
Monitoring the evolution of SARS-CoV-2 on a Spanish university campus through wastewater analysis: A pilot project for the reopening strategyArticle Published on 2022-11-012022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition administration carried Christma collected conducted COVID-19 COVID-19 incidence defined Epidemiology Evolution Evolution of SARS-CoV-2 Frequency implementation improvement knowledge monitoring Mutation occurred outbreak pandemic populations Probability returned SARS-CoV-2 SARS-CoV-2 RNA detection selected Sequencing sewage Spain Spanish Surveillance symptomatic and asymptomatic transmission of SARS-CoV-2 university University campus viral variant virus virus variants wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.157370 PMC 바로가기
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patientsArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Affect anti-CD20 anti-CD20 treatment antibody Antibody Response Antibody titers B cell B cells B-cell B-cell depletion Blood booster cellular response Cohort correlated detectable develop Efficacy Guidance humoral identify IgG^{+} interleukin-13 Logistic regression median memory multiple sclerosis naïve no correlation Odds ratio Patient patients predict predictor Probability recent rituximab S1 domain SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Seroconversion T-cell Response treated Treatment turn vaccination vaccination. vaccine responses [DOI] 10.1111/ene.15492 PMC 바로가기
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIVArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Analysis Antibody Response CD4 CD4 cell CD4 count CD4 T-cell CD4 T-cell counts Cluster Complete COVID-19 vaccine COVID-19 vaccines determine dose evaluated Humoral response IgG IgG antibody immunization Immunosuppression impair individual log median mRNA multicentre neutralization Neutralizing antibodies Patient people living with HIV PLWH predictor Probability prospective cohort study quantitative determination receiving response to vaccination SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion Specific the antibody response the vaccine vaccination Vaccine vaccine. with HIV [DOI] 10.1016/j.cmi.2022.05.018 PMC 바로가기